Research Paper Volume 13, Issue 17 pp 21451—21469

Identification and epidemiological evaluation of gastric cancer risk factors: based on a field synopsis and meta-analysis in Chinese population

The distribution of genetic variants that were significantly related to the risk of gastric cancer based on the main function of genes. (A) Inflammatory related genes (COX-2 rs20417(C), IL-17A rs2275913, IL-17A rs8193036, TGFBR2 rs3773651, IL-10 rs1800896 and VDR rs731236). (B) B+Metabolic pathway related genes (MTHFR rs1801133, NAT2 rs1799930, NAT2 rs1799929, NAT2 phenotype, GSTM1 and GSTT1). (C) A+B+Signal pathway related gene (PLCE1 rs2274223, PLCE1 rs3765524, PSCA rs2294008, PSCA rs2976392, PRKAA1 rs13361707 and MUC1 rs4072037). (D) A+B+C+Base excision repair pathway related gene (XRCC1 rs1799782, XRCC1 rs25487, XRCC3 rs861539 and ERCC5 rs751402).

Figure 4. The distribution of genetic variants that were significantly related to the risk of gastric cancer based on the main function of genes. (A) Inflammatory related genes (COX-2 rs20417(C), IL-17A rs2275913, IL-17A rs8193036, TGFBR2 rs3773651, IL-10 rs1800896 and VDR rs731236). (B) B+Metabolic pathway related genes (MTHFR rs1801133, NAT2 rs1799930, NAT2 rs1799929, NAT2 phenotype, GSTM1 and GSTT1). (C) A+B+Signal pathway related gene (PLCE1 rs2274223, PLCE1 rs3765524, PSCA rs2294008, PSCA rs2976392, PRKAA1 rs13361707 and MUC1 rs4072037). (D) A+B+C+Base excision repair pathway related gene (XRCC1 rs1799782, XRCC1 rs25487, XRCC3 rs861539 and ERCC5 rs751402).