Research Paper Volume 13, Issue 17 pp 20935—20961

Hyperbaric oxygen therapy alleviates vascular dysfunction and amyloid burden in an Alzheimer’s disease mouse model and in elderly patients

HBOT improves performance of 5XFAD mice in cognitive tasks. (A) In the Y-maze test, HBO-treated 5XFAD mice showed better spatial memory as reflected in the time index, which is displayed as the ratio (novel /novel + familiar) to time in each arm. (B) In the trace fear conditioning assay, mice underwent conditioning involving 6 rounds of tone-shock pairing with a trace interval. On the following day, the mice were exposed to the same context with no exposure to tone or shock. Results of contextual freezing are expressed as the percent of total time spent frozen in the training context. Two-way ANOVA with/without repeated measures and post-hoc Fisher LSD tests were performed. Values represent means ± SEM. *P P P

Figure 7. HBOT improves performance of 5XFAD mice in cognitive tasks. (A) In the Y-maze test, HBO-treated 5XFAD mice showed better spatial memory as reflected in the time index, which is displayed as the ratio (novel /novel + familiar) to time in each arm. (B) In the trace fear conditioning assay, mice underwent conditioning involving 6 rounds of tone-shock pairing with a trace interval. On the following day, the mice were exposed to the same context with no exposure to tone or shock. Results of contextual freezing are expressed as the percent of total time spent frozen in the training context. Two-way ANOVA with/without repeated measures and post-hoc Fisher LSD tests were performed. Values represent means ± SEM. *P < 0.05, **P < 0.01, *** P < 0.001.