Research Paper Volume 13, Issue 17 pp 21470—21482

SCFAs promote intestinal double-negative T cells to regulate the inflammatory response mediated by NLRP3 inflammasome

Effect of SCFAs on the cognitive ability, DNTs differentiation and expression of inflammatory factor in AD mice. (A–C) Results of Morris water maze in mice (x¯ ± s, n = 10): Compared with WT group at the same time point, *P #P D–F) Results of DNTs test (x¯ ± s, n = 10) in vivo: Comparison of proportion of DNTs in the spleen in (E), and comparison of proportion of DNTs in the intestine in (F). Statistical significance between the groups, P G–I) The expression levels of inflammatory factors (IL-1β, IL-6 and TNF-α) in peripheral blood, intestine and brain of mice (x¯ ± s, n = 10): Comparison with WT group, *P #P

Figure 1. Effect of SCFAs on the cognitive ability, DNTs differentiation and expression of inflammatory factor in AD mice. (AC) Results of Morris water maze in mice (x¯ ± s, n = 10): Compared with WT group at the same time point, *P < 0.05; comparison with AD group at the same time point, #P < 0.05. (DF) Results of DNTs test (x¯ ± s, n = 10) in vivo: Comparison of proportion of DNTs in the spleen in (E), and comparison of proportion of DNTs in the intestine in (F). Statistical significance between the groups, P < 0.05. (GI) The expression levels of inflammatory factors (IL-1β, IL-6 and TNF-α) in peripheral blood, intestine and brain of mice (x¯ ± s, n = 10): Comparison with WT group, *P < 0.05; comparison with AD group, #P < 0.05.