Research Paper Volume 13, Issue 16 pp 20836—20852

Heparanase is a novel biomarker for immune infiltration and prognosis in breast cancer

HPSE expression in different types of human cancers, and relationship between HPSE expression and clinicopathological parameters in breast cancer patients. (A) Increased or decreased HPSE in data sets of different cancers compared with normal tissues in the Oncomine database. The graphic demonstrates the numbers of datasets with statistically upregulated (red) or downregulated (blue) expression of the target mRNA. The grid color is determined by the best gene rank percentile for the analyses within the grid. The Arabic number in each grid represents the number of analyses that met the criteria Gene HPSE. The gene rank was analyzed by the percentile of target genes of HPSE in the top of all genes measured. (B) Human HPSE expression in different tumor types in TCGA database determined by TIMER (*P C), age (D), SBR (E), NPI (F), and P53 status (G).

Figure 1. HPSE expression in different types of human cancers, and relationship between HPSE expression and clinicopathological parameters in breast cancer patients. (A) Increased or decreased HPSE in data sets of different cancers compared with normal tissues in the Oncomine database. The graphic demonstrates the numbers of datasets with statistically upregulated (red) or downregulated (blue) expression of the target mRNA. The grid color is determined by the best gene rank percentile for the analyses within the grid. The Arabic number in each grid represents the number of analyses that met the criteria Gene HPSE. The gene rank was analyzed by the percentile of target genes of HPSE in the top of all genes measured. (B) Human HPSE expression in different tumor types in TCGA database determined by TIMER (*P < 0.05, **P < 0.01, ***P < 0.001). The results are shown for the relationship between HPSE expression and SCM3 intrinsic molecular subtype (C), age (D), SBR (E), NPI (F), and P53 status (G).