Research Paper Volume 13, Issue 17 pp 20915—20934

Reduced uremic metabolites are prominent feature of sarcopenia, distinct from antioxidative markers for frailty

The metabolomic study of sarcopenia. (A) Overview of the study protocol. All participants were clinically assessed, and their blood was evaluated by untargeted whole-blood metabolomics. This study was conducted using previously reported clinical data from 19 elderly participants who were also assessed for sarcopenia. (B) Comparison of SMI between sarcopenic and non-sarcopenic subjects. SMI was significantly decreased in the sarcopenia group. (C) Pearson's correlation of the linear model between hand grip and SMI (left panel). The correlation coefficient between hand grip and SMI was statistically significant (R = 0.60, p = 0.007). The correlation between MoCA-J and SMI was not statistically significant (R = 0.25, p = 0.31). (D) Serum creatine kinase levels decreased significantly in sarcopenia. (E) Serum creatinine decreased significantly in sarcopenia and the low-SMI group. (F) Metabolomic analysis by LC-MS detected a significant decrease of creatinine in sarcopenia and the low-SMI group. *p **p

Figure 1. The metabolomic study of sarcopenia. (A) Overview of the study protocol. All participants were clinically assessed, and their blood was evaluated by untargeted whole-blood metabolomics. This study was conducted using previously reported clinical data from 19 elderly participants who were also assessed for sarcopenia. (B) Comparison of SMI between sarcopenic and non-sarcopenic subjects. SMI was significantly decreased in the sarcopenia group. (C) Pearson's correlation of the linear model between hand grip and SMI (left panel). The correlation coefficient between hand grip and SMI was statistically significant (R = 0.60, p = 0.007). The correlation between MoCA-J and SMI was not statistically significant (R = 0.25, p = 0.31). (D) Serum creatine kinase levels decreased significantly in sarcopenia. (E) Serum creatinine decreased significantly in sarcopenia and the low-SMI group. (F) Metabolomic analysis by LC-MS detected a significant decrease of creatinine in sarcopenia and the low-SMI group. *p < 0.05. Error bars represent means ± SD. **p < 0.01. Error bars represent means ± SD.