Research Paper Volume 13, Issue 17 pp 20915—20934

Reduced uremic metabolites are prominent feature of sarcopenia, distinct from antioxidative markers for frailty

Summary of 25 metabolites related to sarcopenia and 15 frailty markers. 15 frailty markers (blue box) and 22 sarcopenia markers (dark green box) are presented. There is no overlap among them. 10 metabolites are muscle mass-related markers (light green box). Seven of the 15 frailty markers were antioxidants; however, sarcopenia markers include no antioxidants. Seven metabolites (isovaleryl-carnitine, 2-oxoglutarate, cis-aconitate, creatinine, dimethyl-arginine, dimethyl-guanosine, and N1-methyl-histidine) are both sarcopenia and muscle mass-related markers. 21 metabolites in orange are kidney-related markers.

Figure 5. Summary of 25 metabolites related to sarcopenia and 15 frailty markers. 15 frailty markers (blue box) and 22 sarcopenia markers (dark green box) are presented. There is no overlap among them. 10 metabolites are muscle mass-related markers (light green box). Seven of the 15 frailty markers were antioxidants; however, sarcopenia markers include no antioxidants. Seven metabolites (isovaleryl-carnitine, 2-oxoglutarate, cis-aconitate, creatinine, dimethyl-arginine, dimethyl-guanosine, and N1-methyl-histidine) are both sarcopenia and muscle mass-related markers. 21 metabolites in orange are kidney-related markers.