Research Paper Volume 13, Issue 17 pp 21642—21658

Astrocyte-derived exosomes protect hippocampal neurons after traumatic brain injury by suppressing mitochondrial oxidative stress and apoptosis

AS-Exos reduce TBI-induced brain edema, lesion volume and neuronal damage. (A) Hippocampus water content, (B) Cortex water content, and (C) Lesion volume in the hippocampal tissues of TBI, TBI+AS-Exo, Sham, and Sham+AS-Exo groups of rats. (D) Representative H&E stained images of hippocampal tissue sections from TBI, TBI+AS-Exo, Sham, and Sham+AS-Exo groups of rats. (E) Quantitative analysis shows the number of viable neurons per 250 μm length of the CA1 pyramidal cell layer in the H&E stained hippocampal tissue section from the four groups of rats. All data are represented as means ± SEM (n = 8 per group). Statistical significance was determined using one-way ANOVA followed by post-hoc Bonferroni correction. #P ##P *P **P

Figure 3. AS-Exos reduce TBI-induced brain edema, lesion volume and neuronal damage. (A) Hippocampus water content, (B) Cortex water content, and (C) Lesion volume in the hippocampal tissues of TBI, TBI+AS-Exo, Sham, and Sham+AS-Exo groups of rats. (D) Representative H&E stained images of hippocampal tissue sections from TBI, TBI+AS-Exo, Sham, and Sham+AS-Exo groups of rats. (E) Quantitative analysis shows the number of viable neurons per 250 μm length of the CA1 pyramidal cell layer in the H&E stained hippocampal tissue section from the four groups of rats. All data are represented as means ± SEM (n = 8 per group). Statistical significance was determined using one-way ANOVA followed by post-hoc Bonferroni correction. #P < 0.05 or ##P < 0.01 vs. Sham group; *P < 0.05 or **P < 0.01 vs. TBI group.