Figure 4. Rewired glutathione metabolism in aged mouse kidney tissue. The transcriptomic profile was plotted according to the glutathione metabolic pathway (A). Relative intensities of the serum glutathione levels in young (n = 4) and old (n = 4) mice as determined by LC-MS analysis (B). Circulating systemic serum glutathione appeared to be decreased in the old group compared to the young group, but the difference was not significance (p-value: 0.1143). Wilcoxon rank sum test was performed to determine whether glutathione was decreased in the old group.