Research Paper Volume 13, Issue 17 pp 21671—21699

Integrated analysis identifies TfR1 as a prognostic biomarker which correlates with immune infiltration in breast cancer

Association between TfR1 expression and infiltration abundances of diverse immune cells in BC. (A) TfR1 expression was significantly and positively correlated with the infiltration abundances of six types of immune cells in BC in the TIMER database. (B) Visualization of the infiltrating levels of multiple immune cells in the BC samples. (C) Comparison of the proportions of immune cells in the TfR1 high-expression and low-expression groups. (D) TfR1 expression was significantly associated with the infiltration abundances of diverse immune cells in BC using the CIBERSORT algorithm. (E) Correlations between TfR1 expression and the infiltration abundances of selected immune cells in BC through CIBERSORT algorithm. (F) The expression of various immune checkpoint genes between the TfR1 low-expression group and the high-expression group. *p **p ***p

Figure 11. Association between TfR1 expression and infiltration abundances of diverse immune cells in BC. (A) TfR1 expression was significantly and positively correlated with the infiltration abundances of six types of immune cells in BC in the TIMER database. (B) Visualization of the infiltrating levels of multiple immune cells in the BC samples. (C) Comparison of the proportions of immune cells in the TfR1 high-expression and low-expression groups. (D) TfR1 expression was significantly associated with the infiltration abundances of diverse immune cells in BC using the CIBERSORT algorithm. (E) Correlations between TfR1 expression and the infiltration abundances of selected immune cells in BC through CIBERSORT algorithm. (F) The expression of various immune checkpoint genes between the TfR1 low-expression group and the high-expression group. *p < 0.05, **p < 0.01, ***p < 0.001.