Research Paper Volume 13, Issue 17 pp 21712—21728

The ceRNA PVT1 inhibits proliferation of ccRCC cells by sponging miR-328-3p to elevate FAM193B expression

PVT1 and FAM193B are highly expressed and associated with poor outcome in several cancers. (A–C) Risk score analysis of Shanghai General Hospital ccRCC (A), BC (B) and EC (C) patient cohorts. The risk score and patient distribution were visualized with the best cut-off value. (D–F). Patients were divided into low-risk and high-risk groups based on the optimal cut-off point. Kaplan-Meier method was applied to estimate the survival status. (G–I). To compare the sensitivity and specificity of survival predication, ROC analysis of 3- and 5-year OS was performed based on the risk score.

Figure 8. PVT1 and FAM193B are highly expressed and associated with poor outcome in several cancers. (AC) Risk score analysis of Shanghai General Hospital ccRCC (A), BC (B) and EC (C) patient cohorts. The risk score and patient distribution were visualized with the best cut-off value. (DF). Patients were divided into low-risk and high-risk groups based on the optimal cut-off point. Kaplan-Meier method was applied to estimate the survival status. (GI). To compare the sensitivity and specificity of survival predication, ROC analysis of 3- and 5-year OS was performed based on the risk score.