Research Paper Volume 13, Issue 17 pp 21758—21777

The upregulated expression of RFC4 and GMPS mediated by DNA copy number alteration is associated with the early diagnosis and immune escape of ESCC based on a bioinformatic analysis

RFC4 and GMPS expression correlates with tumor-infiltrating immune cells and immune escape in esophageal carcinoma. (A) RFC4 expression was positively correlated with the tumor purity (r = 0.287, p p B) GMPS expression was positively correlated with the tumor purity (r = 0.217, p p p C) A high level of RFC4 accompanied by a high expression of CD4+ T cells (p = 0.0112), CD 8+ T cells (p = 0.0164), B cells (p = 0.00199), dendritic cells (p = 0.0357) and monocytes (p = 0.0349) indicated a poor prognosis. When RFC4 was expressed at low levels, a high expression of B cells (p = 0.0201) was associated with a better prognosis. (D) A high level of GMPS accompanied by a high expression of CD 8+ T cells (p = 0.00804), B cells (p = 0.0384), dendritic cells (p = 0.00685) and monocytes (p = 0.00746) indicated a poor prognosis. When GMPS was expressed at low levels, a high expression of CD 8+ T cells (p = 0.0442) and dendritic cells (p = 0.0164) was associated with a better prognosis. p

Figure 9. RFC4 and GMPS expression correlates with tumor-infiltrating immune cells and immune escape in esophageal carcinoma. (A) RFC4 expression was positively correlated with the tumor purity (r = 0.287, p < 0.05) but negatively correlated with Dendritic cells (r = −0.193, p < 0.05). (B) GMPS expression was positively correlated with the tumor purity (r = 0.217, p < 0.05) but negatively correlated with CD4+ T cells (r = −0.185, p < 0.05) and neutrophils (r =−0.172, p < 0.05). (C) A high level of RFC4 accompanied by a high expression of CD4+ T cells (p = 0.0112), CD 8+ T cells (p = 0.0164), B cells (p = 0.00199), dendritic cells (p = 0.0357) and monocytes (p = 0.0349) indicated a poor prognosis. When RFC4 was expressed at low levels, a high expression of B cells (p = 0.0201) was associated with a better prognosis. (D) A high level of GMPS accompanied by a high expression of CD 8+ T cells (p = 0.00804), B cells (p = 0.0384), dendritic cells (p = 0.00685) and monocytes (p = 0.00746) indicated a poor prognosis. When GMPS was expressed at low levels, a high expression of CD 8+ T cells (p = 0.0442) and dendritic cells (p = 0.0164) was associated with a better prognosis. p < 0.05 was considered significant.