COVID-19 Research Paper Volume 13, Issue 18 pp 21866—21902

Efficacy and safety of current medications for treating severe and non-severe COVID-19 patients: an updated network meta-analysis of randomized placebo-controlled trials

Network plot of eligible comparisons for medications. (A) The VC ratio of non-severe COVID-19 patients. (B) All-cause mortality of non-severe COVID-19 patients. (C) The TEAEs ratio of non-severe COVID-19 patients. (D) All-cause mortality of severe COVID-19 patients. (E) The TEAEs ratio of severe COVID-19 patients. Abbreviations: COVID-19: coronavirus disease 2019; VC: virological cure; TEAEs: treatment-emergent adverse events; PL: peginterferon lambda; LDI: low dosage ivermectin; LPV/r: lopinavir–ritonavir; AZM: azithromycin; HDVD: high-dose vitamin D; HDIVZn: high-dose intravenous zinc: LCP: low dosage CT-P59; HCP: high dosage CT-P59; CPC: CT-P59 combined; HCQ: hydroxychloroquine; LDB: low dosage bamlanivimab; MDB: moderate dosage bamlanivimab; HDB: high dosage bamlanivimab; LS: low dosage sarilumab; HS: high dosage sarilumab; NPF: novel probiotic formulation; CP: convalescent plasma; ALA: α-Lipoic acid; IFN-β: interferon beta; IG: immunoglobulin gamma.

Figure 3. Network plot of eligible comparisons for medications. (A) The VC ratio of non-severe COVID-19 patients. (B) All-cause mortality of non-severe COVID-19 patients. (C) The TEAEs ratio of non-severe COVID-19 patients. (D) All-cause mortality of severe COVID-19 patients. (E) The TEAEs ratio of severe COVID-19 patients. Abbreviations: COVID-19: coronavirus disease 2019; VC: virological cure; TEAEs: treatment-emergent adverse events; PL: peginterferon lambda; LDI: low dosage ivermectin; LPV/r: lopinavir–ritonavir; AZM: azithromycin; HDVD: high-dose vitamin D; HDIVZn: high-dose intravenous zinc: LCP: low dosage CT-P59; HCP: high dosage CT-P59; CPC: CT-P59 combined; HCQ: hydroxychloroquine; LDB: low dosage bamlanivimab; MDB: moderate dosage bamlanivimab; HDB: high dosage bamlanivimab; LS: low dosage sarilumab; HS: high dosage sarilumab; NPF: novel probiotic formulation; CP: convalescent plasma; ALA: α-Lipoic acid; IFN-β: interferon beta; IG: immunoglobulin gamma.