Review Volume 13, Issue 20 pp 23842—23867

Differential expression of long non-coding RNAs as diagnostic markers for lung cancer and other malignant tumors

Molecular mechanism of LncRNA. (A) The main mechanisms of lncRNA epigenetics include histone modification, DNA methylation, gene silencing, and chromatin remodeling. (B) The main if lncRNA transcription level include signal induction, regulation of transcription factor sites, DNA triple helix structure and co-expression of ceRNA. (C) The main mechanisms of lncRNA post-transcriptional level include guiding the selective splicing of miRNA subtypes and targeting the protein receptor complex to recognize righteous chain mRNA transcripts.

Figure 1. Molecular mechanism of LncRNA. (A) The main mechanisms of lncRNA epigenetics include histone modification, DNA methylation, gene silencing, and chromatin remodeling. (B) The main if lncRNA transcription level include signal induction, regulation of transcription factor sites, DNA triple helix structure and co-expression of ceRNA. (C) The main mechanisms of lncRNA post-transcriptional level include guiding the selective splicing of miRNA subtypes and targeting the protein receptor complex to recognize righteous chain mRNA transcripts.