Review Volume 13, Issue 20 pp 23842—23867

Differential expression of long non-coding RNAs as diagnostic markers for lung cancer and other malignant tumors

Flow-chart of diagnosis LncRNA of this study. K = number of literature records. First, identify the published lncRNA biomarkers of diagnosis in lung cancer patients in the NCBI PubMed database. Then, screening 769 database and obtain 287 database. The criteria of record exclusion were as follows: i) Reviews and meta-analysis and bioinformatics; ii) Case report; iii) Article not in English; iv) No lncRNA study; v) Non-human study: cell lines or/and mice; vi) Other disease. Finally, 35 up-regulated lncRNAs and 13 down-regulated lncRNAs in lung cancer were identified from these studies.

Figure 7. Flow-chart of diagnosis LncRNA of this study. K = number of literature records. First, identify the published lncRNA biomarkers of diagnosis in lung cancer patients in the NCBI PubMed database. Then, screening 769 database and obtain 287 database. The criteria of record exclusion were as follows: i) Reviews and meta-analysis and bioinformatics; ii) Case report; iii) Article not in English; iv) No lncRNA study; v) Non-human study: cell lines or/and mice; vi) Other disease. Finally, 35 up-regulated lncRNAs and 13 down-regulated lncRNAs in lung cancer were identified from these studies.