Research Paper Volume 13, Issue 18 pp 22208—22231

Involvement of c-Myc in low dose radiation-induced senescence enhanced migration and invasion of unirradiated cancer cells

Effects of c-Myc inhibitor on LDR irradiated NSCLC xenograft tumor. (A) Design of xenograft tumor model for treatment of LDR and c-Myc inhibitor. (B) Detection of c-Myc and K-Ras protein expression in LDR irradiated tumors formed by H1299 cells. (C) Measurement of tumor growth by caliper after LDR irradiation (0.5Gy) with or without the treatment of 10058-F4 (25 mg/kg). (D) Comparison of tumor sizes excised from tumor-bearing mice with different treatment for 3 weeks. *p

Figure 7. Effects of c-Myc inhibitor on LDR irradiated NSCLC xenograft tumor. (A) Design of xenograft tumor model for treatment of LDR and c-Myc inhibitor. (B) Detection of c-Myc and K-Ras protein expression in LDR irradiated tumors formed by H1299 cells. (C) Measurement of tumor growth by caliper after LDR irradiation (0.5Gy) with or without the treatment of 10058-F4 (25 mg/kg). (D) Comparison of tumor sizes excised from tumor-bearing mice with different treatment for 3 weeks. *p < 0.05.