Research Paper Volume 13, Issue 18 pp 22242—22255

miR-21 regulates ischemic neuronal injury via the p53/Bcl-2/Bax signaling pathway

miR-21 protected OGD/R-induced injury by inhibiting p53-Bcl-2/Bax signaling in vitro. (A) Effect of miR-21/p53 axis on the percentage of TUNEL+ cells. Scale bar, 50μm. (B) Effect of miR-21/p53 axis on the percentage of early, late, and total apoptosis. All experiments were independently repeated three times. *, compared with blank control. *P≤0.05. #, compared with miR-21 mimic + vector group. #P≤0.05.

Figure 4. miR-21 protected OGD/R-induced injury by inhibiting p53-Bcl-2/Bax signaling in vitro. (A) Effect of miR-21/p53 axis on the percentage of TUNEL+ cells. Scale bar, 50μm. (B) Effect of miR-21/p53 axis on the percentage of early, late, and total apoptosis. All experiments were independently repeated three times. *, compared with blank control. *P≤0.05. #, compared with miR-21 mimic + vector group. #P≤0.05.