Research Paper Volume 13, Issue 18 pp 22332—22344

METTL3-mediated m6A modification of KIF3C-mRNA promotes prostate cancer progression and is negatively regulated by miR-320d

KIF3C silence prevented the proliferation migration and invasion of PC cells. (A, B) RT-qPCR and western blotting showing KIF3C expression in PCa cell lines. (C, D) RT qPCR and western blotting showing KIF3C knockdown expression in C4–2B and DU145 cells. (E, F) CCK8 and cloning formation assays showing proliferation after KIF3C knockdown in PCa cells. (G) Transwell showing invasiveness and migration capability of PCa cells after knocking down KIF3C. Data are reported as means ± standard deviation of three independent experiments. *p

Figure 2. KIF3C silence prevented the proliferation migration and invasion of PC cells. (A, B) RT-qPCR and western blotting showing KIF3C expression in PCa cell lines. (C, D) RT qPCR and western blotting showing KIF3C knockdown expression in C4–2B and DU145 cells. (E, F) CCK8 and cloning formation assays showing proliferation after KIF3C knockdown in PCa cells. (G) Transwell showing invasiveness and migration capability of PCa cells after knocking down KIF3C. Data are reported as means ± standard deviation of three independent experiments. *p < 0.05; **p < 0.01.