Research Paper Volume 13, Issue 18 pp 22375—22389

A new mechanism of POCD caused by sevoflurane in mice: cognitive impairment induced by cross-dysfunction of iron and glucose metabolism

Effect of Sev on the levels of brain iron and the expression of iron metabolism-related proteins in elder mice. The mice were treated with Sev as described in Materials and Methods. (A, B) showed the iron levels of cortex and hippocampus of mice between control group and Sev group (The larger the red area, the greater the iron content). (C–F) showed the effect of Sev on the expression of FtL, FtH, and TfR1 in cortex and hippocampus. The western blot results were calculated as the ratios ± SD (n = 5) of the FtL, FtH, and TfR1 band intensities relative to that of actin. **P

Figure 3. Effect of Sev on the levels of brain iron and the expression of iron metabolism-related proteins in elder mice. The mice were treated with Sev as described in Materials and Methods. (A, B) showed the iron levels of cortex and hippocampus of mice between control group and Sev group (The larger the red area, the greater the iron content). (CF) showed the effect of Sev on the expression of FtL, FtH, and TfR1 in cortex and hippocampus. The western blot results were calculated as the ratios ± SD (n = 5) of the FtL, FtH, and TfR1 band intensities relative to that of actin. **P < 0.01 and *P < 0.05 compared with the control group by ANOVA, respectively.