Research Paper Volume 13, Issue 18 pp 22375—22389

A new mechanism of POCD caused by sevoflurane in mice: cognitive impairment induced by cross-dysfunction of iron and glucose metabolism

Sev increased ROS production, reduced mitochondrial membrane potential, and promoted cell apoptosis. The mice were treated with Sev as described in Materials and Methods. (A, B) Showed the ROS levels in cortex and hippocampus. (C, D) Showed the MMP levels in cortex and hippocampus. (E, F) Showed the expression of Bcl2, Bax and the ratio of Bcl2/Bax. Data are expressed as mean±SD, n=5 (**p

Figure 4. Sev increased ROS production, reduced mitochondrial membrane potential, and promoted cell apoptosis. The mice were treated with Sev as described in Materials and Methods. (A, B) Showed the ROS levels in cortex and hippocampus. (C, D) Showed the MMP levels in cortex and hippocampus. (E, F) Showed the expression of Bcl2, Bax and the ratio of Bcl2/Bax. Data are expressed as mean±SD, n=5 (**p<0.01vs.control group, *p<0.05 vs. control group).