Research Paper Volume 13, Issue 18 pp 22375—22389

A new mechanism of POCD caused by sevoflurane in mice: cognitive impairment induced by cross-dysfunction of iron and glucose metabolism

Sev decreased the production of ATP, inhibited the activity of Na+/K+ATPase and changed OCR. (A, B) showed the ATP production in cortex and hippocampus tested by ATP assay kit. (C, D) represented the Na+/K+ATPase activity in cortex and hippocampus, respectively. (E) The OCR was determined using Seahorse XFp8 as described in the Materials and Methods section. Data represented mean ± SD, n=5 (**p

Figure 5. Sev decreased the production of ATP, inhibited the activity of Na+/K+ATPase and changed OCR. (A, B) showed the ATP production in cortex and hippocampus tested by ATP assay kit. (C, D) represented the Na+/K+ATPase activity in cortex and hippocampus, respectively. (E) The OCR was determined using Seahorse XFp8 as described in the Materials and Methods section. Data represented mean ± SD, n=5 (**p<0.01vs. control group, *p<0.05 vs. control group).