Research Paper Volume 13, Issue 18 pp 22375—22389

A new mechanism of POCD caused by sevoflurane in mice: cognitive impairment induced by cross-dysfunction of iron and glucose metabolism

Sev inhibited the absorption of glucose by downregulating the expression of Glut1 in vascular endothelial cells, rather than glucose receptor 3 in nerve cells. Effect of Sev on the mRNA expression of Glut1 (A, B) and Glut3 (C, D) and the protein expression of Glut1 (E, F) and Glut3 (G, H) in cortex and hippocampus. (I–L) Showed the Glut1 and Glut3 expression in vascular endothelial cells and neurons of cortex and hippocampus by immunofluorescence, respectively. Data are expressed as mean±SD, n=5 (**p

Figure 7. Sev inhibited the absorption of glucose by downregulating the expression of Glut1 in vascular endothelial cells, rather than glucose receptor 3 in nerve cells. Effect of Sev on the mRNA expression of Glut1 (A, B) and Glut3 (C, D) and the protein expression of Glut1 (E, F) and Glut3 (G, H) in cortex and hippocampus. (IL) Showed the Glut1 and Glut3 expression in vascular endothelial cells and neurons of cortex and hippocampus by immunofluorescence, respectively. Data are expressed as mean±SD, n=5 (**p<0.01vs. control group, *p<0.05 vs. control group).