Research Paper Volume 13, Issue 18 pp 21962—21974

Dulaglutide improves muscle function by attenuating inflammation through OPA-1-TLR-9 signaling in aged mice

Dulaglutide increases muscle weight in aged mice. (A) Body weight changes in mice (B) Total muscle weight and, (C) Weight of the five muscle types, including gastrocnemius (GA), tibialis anterior (TA), quadriceps (QD), extensor digitorum longus (EDL), and soleus (SOL). The muscle weights were normalized to the body weight (g). The total muscle weight indicates the sum of all muscle weight such as SOL, TA, QD, GA, and EDL. All values are expressed as the mean ± SE. Significant differences are indicated as ** p p

Figure 1. Dulaglutide increases muscle weight in aged mice. (A) Body weight changes in mice (B) Total muscle weight and, (C) Weight of the five muscle types, including gastrocnemius (GA), tibialis anterior (TA), quadriceps (QD), extensor digitorum longus (EDL), and soleus (SOL). The muscle weights were normalized to the body weight (g). The total muscle weight indicates the sum of all muscle weight such as SOL, TA, QD, GA, and EDL. All values are expressed as the mean ± SE. Significant differences are indicated as ** p < 0.01 or * p < 0.05 compared to young mice + vehicle or ## p < 0.01 or # p < 0.05 compared to aged mice + vehicle. N = 5–8/group.