Research Paper Volume 13, Issue 18 pp 21962—21974

Dulaglutide improves muscle function by attenuating inflammation through OPA-1-TLR-9 signaling in aged mice

Dulaglutide increases muscle function and myofiber size. (A) Grip strengths were normalized to body weight (g). (B) Representative image of hematoxylin and eosin (H&E) stained muscle tissues (C) Cross-sectional area (CSA) of TA muscle tissue. Magnification ×200 (D) Muscle fiber size distribution. All values are expressed as the mean ± SE. Solid black line indicates young mice + vehicle, black dotted line indicates young mice + dulaglutide, solid red line indicates aged mice + vehicle, and red dotted line indicates aged mice + dulaglutide. Significant differences are indicated as ** p p

Figure 2. Dulaglutide increases muscle function and myofiber size. (A) Grip strengths were normalized to body weight (g). (B) Representative image of hematoxylin and eosin (H&E) stained muscle tissues (C) Cross-sectional area (CSA) of TA muscle tissue. Magnification ×200 (D) Muscle fiber size distribution. All values are expressed as the mean ± SE. Solid black line indicates young mice + vehicle, black dotted line indicates young mice + dulaglutide, solid red line indicates aged mice + vehicle, and red dotted line indicates aged mice + dulaglutide. Significant differences are indicated as ** p < 0.01 or * p < 0.05 compared to young mice + vehicle or aged mice + vehicle. N = 5–8/group.