Research Paper Volume 13, Issue 18 pp 21962—21974

Dulaglutide improves muscle function by attenuating inflammation through OPA-1-TLR-9 signaling in aged mice

Dulaglutide decreases muscle atrophic factors in aged mice. (A) mRNA expression of myostatin (MSTN), atrogin-1, and muscle RING-finger protein-1 (MuRF-1) in the TA muscle (B) Protein levels of MSTN, atrogin-1, and MuRF-1 in the TA muscle (C) Protein level of myogenic factors, MyoD and myogenin (MyoG) in the TA muscle. All values are expressed as the mean ± SE. Significant differences are indicated as ***p p p

Figure 3. Dulaglutide decreases muscle atrophic factors in aged mice. (A) mRNA expression of myostatin (MSTN), atrogin-1, and muscle RING-finger protein-1 (MuRF-1) in the TA muscle (B) Protein levels of MSTN, atrogin-1, and MuRF-1 in the TA muscle (C) Protein level of myogenic factors, MyoD and myogenin (MyoG) in the TA muscle. All values are expressed as the mean ± SE. Significant differences are indicated as ***p < 0.001, ** p < 0.01, or * p < 0.05 compared to young mice + vehicle or aged mice + vehicle. N = 5–8/group.