Research Paper Volume 13, Issue 18 pp 22444—22458

SUV39H2/KMT1B Inhibits the cardiomyocyte senescence phenotype by down-regulating BTG2/PC3

RNA-seq of knockdown SUV39H2 in cardiomyocytes induced by H2O2. (A–D) Following 50 μM H2O2 treatment of the PLKO and sh-SUV39H2 groups, RNA-Seq data processing. (A) Heat map showing the differential gene expression between the two groups. (B) Volcano map showing that there were 3,825 up-regulated genes and 4,014 down-regulated genes between the two groups. (C) Bubble chart showing the top 10 enrichment paths from GO and KEGG analyses. (D) Quantification of the differential genes after RNA-Seq analyses of the cells of the two groups. *P **P ***P

Figure 4. RNA-seq of knockdown SUV39H2 in cardiomyocytes induced by H2O2. (AD) Following 50 μM H2O2 treatment of the PLKO and sh-SUV39H2 groups, RNA-Seq data processing. (A) Heat map showing the differential gene expression between the two groups. (B) Volcano map showing that there were 3,825 up-regulated genes and 4,014 down-regulated genes between the two groups. (C) Bubble chart showing the top 10 enrichment paths from GO and KEGG analyses. (D) Quantification of the differential genes after RNA-Seq analyses of the cells of the two groups. *P < 0.05, **P < 0.01, ***P < 0.005 when two groups were compared as indicated, or compared to the corresponding control.