Research Paper Volume 13, Issue 18 pp 22459—22473

miR-19b-3p relieves intervertebral disc degeneration through modulating PTEN/PI3K/Akt/mTOR signaling pathway

The effect of overexpressing miR-19b-3p on the PTEN/PI3K/Akt/mTOR axis. In the in-vitro IVDD model, HNPCs were transfected with miR-19b-3p mimics.. (A, B) WB was adopted to determine the PTEN/PI3K/Akt/mTOR expression. * P P P P P P

Figure 4. The effect of overexpressing miR-19b-3p on the PTEN/PI3K/Akt/mTOR axis. In the in-vitro IVDD model, HNPCs were transfected with miR-19b-3p mimics.. (A, B) WB was adopted to determine the PTEN/PI3K/Akt/mTOR expression. * P <0.05, ** P <0.01, *** P <0.001(vs. control group). & P <0.05, && P <0.01, &&& P <0.001(vs. the IL-1β/TNF-α/hydrogen peroxide group). N=3.