Research Paper Volume 13, Issue 18 pp 22490—22501

Nesfatin-1 facilitates IL-1β production in osteoarthritis synovial fibroblasts by suppressing miR-204-5p synthesis through the AP-1 and NF-κB pathways

Higher levels of nesfatin-1 and IL-1β in OA synovial tissue than in tissue from healthy controls. (A and B) Levels of nesfatin-1 and IL-1β in normal and OA synovial tissues retrieved from the GEO dataset. (C and D) ELISA analysis showing higher serum levels of nesfatin-1 and IL-1β among OA patients compared with healthy controls. *p

Figure 1. Higher levels of nesfatin-1 and IL-1β in OA synovial tissue than in tissue from healthy controls. (A and B) Levels of nesfatin-1 and IL-1β in normal and OA synovial tissues retrieved from the GEO dataset. (C and D) ELISA analysis showing higher serum levels of nesfatin-1 and IL-1β among OA patients compared with healthy controls. *p < 0.05 compared with normal synovial tissue.