Research Paper Volume 13, Issue 18 pp 22490—22501

Nesfatin-1 facilitates IL-1β production in osteoarthritis synovial fibroblasts by suppressing miR-204-5p synthesis through the AP-1 and NF-κB pathways


Figure 6. Schema illustrating the effects of nesfatin-1 upon IL-1β synthesis during OA progression. Nesfatin-1 promotes IL-1β synthesis in human OASFs by suppressing miR-204-5p synthesis in the PI3K, Akt, AP-1 and NF-κB signaling pathways.