COVID-19 Priority Research Paper Volume 13, Issue 18 pp 21838—21854

SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3

Lung p16INK4a+ senescent cell burden is greater in patients dying from acute SARS-CoV-2 than other causes. Lung tissue from patients who died from SARS-CoV-2 (n=9) were compared to controls (n=6) who died from other causes without lung disease (see Supplementary Tables 2, 3). (A) Paraffin-embedded lung autopsy tissue was sectioned and stained for p16INK4a by immunohistochemistry (black arrowheads). (B) Fifteen fields of alveolar tissue were randomly selected and counted. Mean +/- SEM, unpaired 2-tailed Student’s t-test.

Figure 5. Lung p16INK4a+ senescent cell burden is greater in patients dying from acute SARS-CoV-2 than other causes. Lung tissue from patients who died from SARS-CoV-2 (n=9) were compared to controls (n=6) who died from other causes without lung disease (see Supplementary Tables 2, 3). (A) Paraffin-embedded lung autopsy tissue was sectioned and stained for p16INK4a by immunohistochemistry (black arrowheads). (B) Fifteen fields of alveolar tissue were randomly selected and counted. Mean +/- SEM, unpaired 2-tailed Student’s t-test.