Research Paper Volume 13, Issue 18 pp 22502—22515

Melatonin inhibits proliferation, migration, and invasion by inducing ROS-mediated apoptosis via suppression of the PI3K/Akt/mTOR signaling pathway in gallbladder cancer cells

Melatonin inhibited GBC-SD cells proliferation in vivo. (A) Body weights of all mice were recorded every three days (n = 6). (B) The tumor volume was measured every three days (n = 6). (C, D) The pictures of mice and harvested tumors (n = 6). (E) Tumor weight measurements (n = 6). Data are presented as mean ± SD. Mel, melatonin; ***P

Figure 6. Melatonin inhibited GBC-SD cells proliferation in vivo. (A) Body weights of all mice were recorded every three days (n = 6). (B) The tumor volume was measured every three days (n = 6). (C, D) The pictures of mice and harvested tumors (n = 6). (E) Tumor weight measurements (n = 6). Data are presented as mean ± SD. Mel, melatonin; ***P < 0.001.