Research Paper Volume 13, Issue 18 pp 22516—22527

miR-320 accelerates chronic heart failure with cardiac fibrosis through activation of the IL6/STAT3 axis


Figure 1. The expression of STAT3 in cardiomyocyte lines and miR-320 targeted-regulated STAT3. (A) The expression of STAT3 was low in standard samples (green) and high in case samples (red); P < 0.05. (B) Different expressed miRNA volcano map of standard group and case group in GEO dataset; (C) Venn diagram of predicted upstream, down-regulated, differently expressed miRNA for STAT3; (D) A heat map depicting miR-320 was higher in the cardiac fibrosis group, as compared with the controls; (D) GSEA pathway enrichment analysis results of STAT3; (E) Correlation analysis found that miR-320 was negatively correlated with KLF9 protein expression in cardiac tissues. (F) The relative expression levels of serum miR-320 were significantly elevated in patients with cardiac fibrosis. P < 0.05.