Research Paper Volume 13, Issue 18 pp 22516—22527

miR-320 accelerates chronic heart failure with cardiac fibrosis through activation of the IL6/STAT3 axis

MiR-320 OE induced left ventricular (LV) hypertrophy and cardiac fibrosis. (A) Representative serial M-mode echocardiography in conscious sham and miR-320 OE and model mice measured before and after TAC; (B) Summary data of left ventricular internal dimension diastole (LVIDd), left ventricular internal dimension systole (LVIDs), left ventricular posterior wall dimensions diastole (LVPWd), left ventricular posterior wall dimensions systole (LVPWDs), and ejection fraction (E.F.). P

Figure 2. MiR-320 OE induced left ventricular (LV) hypertrophy and cardiac fibrosis. (A) Representative serial M-mode echocardiography in conscious sham and miR-320 OE and model mice measured before and after TAC; (B) Summary data of left ventricular internal dimension diastole (LVIDd), left ventricular internal dimension systole (LVIDs), left ventricular posterior wall dimensions diastole (LVPWd), left ventricular posterior wall dimensions systole (LVPWDs), and ejection fraction (E.F.). P < 0.05; miR-320 OE vs. model and sham vs. model.