Research Paper Volume 13, Issue 18 pp 22516—22527

miR-320 accelerates chronic heart failure with cardiac fibrosis through activation of the IL6/STAT3 axis

MiR-320 OE accelerated cardiac function damage with significant cardiac fibrosis. (A) The histological assessment was performed to evaluate cardiac morphology between the model, miR-320 OE, and miR-320 OE + BP-1–102 samples. (B) Representative pictures of myocardial connective tissue Masson staining demonstrate cardiac fibrosis and fibrosis area. The quantitative analysis of fibrosis area/total areas, cardiocyte areas, and heart/weight ratio. P

Figure 3. MiR-320 OE accelerated cardiac function damage with significant cardiac fibrosis. (A) The histological assessment was performed to evaluate cardiac morphology between the model, miR-320 OE, and miR-320 OE + BP-1–102 samples. (B) Representative pictures of myocardial connective tissue Masson staining demonstrate cardiac fibrosis and fibrosis area. The quantitative analysis of fibrosis area/total areas, cardiocyte areas, and heart/weight ratio. P < 0.05.