Research Paper Volume 13, Issue 18 pp 22516—22527

miR-320 accelerates chronic heart failure with cardiac fibrosis through activation of the IL6/STAT3 axis

STAT3 was involved in miR-320 mimics-induced development of cardiac hypertrophy and fibrosis. (A) Western blots revealed that BP-1-102 significantly reversed the up-regulated STAT3, p-STAT3, type I and type III collagen, IL6, TGF-β, and down-regulated PTEN. (B) The quantitative analysis illustrated that inhibitor BP-1-102 exposure blunted the up-regulated type I and III collagen, IL6, TGF-β, p-STAT3, and STAT3 expression and enhanced the down-regulated PTEN expression in fibroblasts transfected with miR-320 mimic by BP-1-102. P

Figure 7. STAT3 was involved in miR-320 mimics-induced development of cardiac hypertrophy and fibrosis. (A) Western blots revealed that BP-1-102 significantly reversed the up-regulated STAT3, p-STAT3, type I and type III collagen, IL6, TGF-β, and down-regulated PTEN. (B) The quantitative analysis illustrated that inhibitor BP-1-102 exposure blunted the up-regulated type I and III collagen, IL6, TGF-β, p-STAT3, and STAT3 expression and enhanced the down-regulated PTEN expression in fibroblasts transfected with miR-320 mimic by BP-1-102. P < 0.05.