Research Paper Volume 13, Issue 18 pp 22544—22555

Glaucocalyxin B inhibits cartilage inflammatory injury in rheumatoid arthritis by regulating M1 polarization of synovial macrophages through NF-κB pathway

The effect of Gla B on cartilage injury in RA. (A) H and E and safranin-O-Green staining showed no obvious injury and no inflammatory response of cartilage tissue in Control mice. The cartilage tissue was severely damaged in RA mice, with obvious inflammatory response. Gla B could inhibit the cartilage injury and inhibit the inflammatory response in RA mice. (B) The clinical pathological score of RA showed that the score was low in Control group, without obvious pathological change. The score was significantly up-regulated in RA, higher than that in Control group. Gla B could decrease the pathological score. Comparison with Control, *P #P

Figure 5. The effect of Gla B on cartilage injury in RA. (A) H and E and safranin-O-Green staining showed no obvious injury and no inflammatory response of cartilage tissue in Control mice. The cartilage tissue was severely damaged in RA mice, with obvious inflammatory response. Gla B could inhibit the cartilage injury and inhibit the inflammatory response in RA mice. (B) The clinical pathological score of RA showed that the score was low in Control group, without obvious pathological change. The score was significantly up-regulated in RA, higher than that in Control group. Gla B could decrease the pathological score. Comparison with Control, *P < 0.05; comparison with RA, #P < 0.05.