Research Paper Volume 13, Issue 18 pp 22588—22610

GPR43 regulation of mitochondrial damage to alleviate inflammatory reaction in sepsis

The inhibition of GPR43 gene is associated with future risk of sepsis-induced inflammatory reactions. Survival rate (A) in tissue of CLP mice for 72 h; W/D rate (B), lung injury score (C) and lung tissue using HE staining (D) in CLP mice for 24 h; IL-6 (E), IL-10 (F), IL-12 (G) and INF-γ (H) levels in tissue of CLP mice for 24 h; IL-6 (I), IL-10 (J), IL-12 (K) and INF-γ (L) levels in serum of CLP mice for 24 h. WT, WT mice with CLP; GPR43-/-, GPR43-/- mice with CLP. ##p

Figure 1. The inhibition of GPR43 gene is associated with future risk of sepsis-induced inflammatory reactions. Survival rate (A) in tissue of CLP mice for 72 h; W/D rate (B), lung injury score (C) and lung tissue using HE staining (D) in CLP mice for 24 h; IL-6 (E), IL-10 (F), IL-12 (G) and INF-γ (H) levels in tissue of CLP mice for 24 h; IL-6 (I), IL-10 (J), IL-12 (K) and INF-γ (L) levels in serum of CLP mice for 24 h. WT, WT mice with CLP; GPR43-/-, GPR43-/- mice with CLP. ##p<0.01 compared with WT mice with CLP.