Research Paper Volume 13, Issue 22 pp 24560—24579

Circular RNA CELF1 drives immunosuppression and anti-PD1 therapy resistance in non-small cell lung cancer via the miR-491-5p/EGFR axis

Inhibition of EGFR prevents cell progression in stabled circ

Figure 7. Inhibition of EGFR prevents cell progression in stabled circ_CELF1 expressed NSCLC cells. (A) The knockdown efficiency of AZD-9291 was confirmed by qRT-PCR. n = 4, *P < 0.05. (B) CCK-8 assay was performed to detect the effect of MK-1775 in NSCLC cells. n = 4, *P < 0.05. (C) The cell cycle was explored by flow cytometry in NSCLC cells after miR-491-5p transfection. n = 4, *P < 0.05. (D) The invasion ability was explored by Transwell. n = 4, *P < 0.05.