Research Paper Volume 13, Issue 18 pp 22092—22108

Adulthood systemic inflammation accelerates the trajectory of age-related cognitive decline

Vehicle and LPS treated animals learn cue and spatial discrimination with no difference in learning or memory at 12 months, 6 months after treatment. Symbols represent mean escape path length (± SEM) for vehicle (open circles) and LPS treated (filled circles) animals over the training blocks for (A) cue and (B) spatial discrimination. (C) Box and whisker plots and individual DI scores from the acquisition, 2 hr and 24 hr probe trials. Pound sign indicates significant difference from chance (p

Figure 1. Vehicle and LPS treated animals learn cue and spatial discrimination with no difference in learning or memory at 12 months, 6 months after treatment. Symbols represent mean escape path length (± SEM) for vehicle (open circles) and LPS treated (filled circles) animals over the training blocks for (A) cue and (B) spatial discrimination. (C) Box and whisker plots and individual DI scores from the acquisition, 2 hr and 24 hr probe trials. Pound sign indicates significant difference from chance (p < 0.05).