Research Paper Volume 13, Issue 18 pp 22092—22108

Adulthood systemic inflammation accelerates the trajectory of age-related cognitive decline

Vehicle and LPS treated animals learn the spatial discrimination and differences in memory emerge at 18 months, 12 months after treatment. Symbols represent mean escape path length (± SEM) for vehicle (open circles) and LPS treated (filled circles) animals over the training blocks for (A) spatial discrimination. (B) Box and whisker plots and individual DI scores from the acquisition, 2 hr and 24 hr probe trials. Pound sign indicates significant difference from chance (p p

Figure 2. Vehicle and LPS treated animals learn the spatial discrimination and differences in memory emerge at 18 months, 12 months after treatment. Symbols represent mean escape path length (± SEM) for vehicle (open circles) and LPS treated (filled circles) animals over the training blocks for (A) spatial discrimination. (B) Box and whisker plots and individual DI scores from the acquisition, 2 hr and 24 hr probe trials. Pound sign indicates significant difference from chance (p < 0.05). Asterisk indicates significant treatment difference (p < 0.05).