Research Paper Volume 13, Issue 21 pp 24071—24085

LncRNA MIR31HG is induced by tocilizumab and ameliorates rheumatoid arthritis fibroblast-like synoviocyte-mediated inflammation via miR-214-PTEN-AKT signaling pathway


Figure 2. The effects of lncRNA MIR31HG on RA-FLS-mediated inflammation. (A) The effects of tocilizumab on endogenous expression of MIR31HG in RA-FLS (n=3). (BE) MIR31HG knockdown affects proliferation, metastasis, and production of inflammatory molecules and MMPs in RA-FLS (n=3). (FJ) RA-FLS with reduced MIR31HG expression regulates primary macrophages and chondrocytes (n=3). Data represent the mean ± SEM; *p < 0.05, Student’s t-test.