Research Paper Volume 13, Issue 21 pp 24071—24085

LncRNA MIR31HG is induced by tocilizumab and ameliorates rheumatoid arthritis fibroblast-like synoviocyte-mediated inflammation via miR-214-PTEN-AKT signaling pathway

The effects of miR-214 overexpression on RA-FLS-mediated inflammation. (A–D) The effects of miR-214 overexpression on proliferation, metastasis, and production of inflammatory molecules and MMPs in RA-FLS (n=3). (E–I) The effects of miR-214 overexpressing RA-FLS on primary macrophages and chondrocytes (n=3). Data represent the mean ± SEM; *p t-test.

Figure 4. The effects of miR-214 overexpression on RA-FLS-mediated inflammation. (AD) The effects of miR-214 overexpression on proliferation, metastasis, and production of inflammatory molecules and MMPs in RA-FLS (n=3). (EI) The effects of miR-214 overexpressing RA-FLS on primary macrophages and chondrocytes (n=3). Data represent the mean ± SEM; *p < 0.05, Student’s t-test.