MiRNA-30e downregulation increases cancer cell proliferation, invasion and tumor growth through targeting RPS6KB1
Figure 5.Analysis of RPS6KB1 and miR-30e expression levels, overall patient survival rate and tumor progression in several types of cancer. (A) Human RPS6KB1 levels in different types of tumor from TCGA were determined using TIMER database (http://timer.comp-genomics.org/), and RPS6KB1 expression is upregulated in most types of tumor. (B) GEPIA (http://gepia.cancer-pku.cn/index.html) was used to analyze the prognostic value of RPS6KB1 expression based on the log-rank test in 10 types of cancer. (C–F) Kaplan-Meier plotter (http://kmplot.com/analysis/), an online database of published microarray datasets, was used to analyze the correlation between miR-30e expression levels and overall patient survival in lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), bladder carcinoma and head and neck squamous cell carcinoma.