Research Paper Volume 13, Issue 21 pp 23936—23952

Impaired glucose metabolism reduces the neuroprotective action of adipocytokines in cognitively normal older adults with insulin resistance

Moderating role of HOMA-IR, triglyceridemia and glycemia in the association between the Ad/L ratio and cognition. Association of the Ad/L ratio with cognition at 1 SD below and above the mean of HOMA-IR for participants showing normal levels of triglycerides (left panel) and hypertriglyceridemia (right panel) (A) or normal blood glucose levels (left panel) and hyperglycemia (right panel) (B) after adjustment of the remaining MtbS components, CRF, BMI, age, sex and years of education. The shaded areas reflect the confidence intervals (95%) for the fitted values.

Figure 1. Moderating role of HOMA-IR, triglyceridemia and glycemia in the association between the Ad/L ratio and cognition. Association of the Ad/L ratio with cognition at 1 SD below and above the mean of HOMA-IR for participants showing normal levels of triglycerides (left panel) and hypertriglyceridemia (right panel) (A) or normal blood glucose levels (left panel) and hyperglycemia (right panel) (B) after adjustment of the remaining MtbS components, CRF, BMI, age, sex and years of education. The shaded areas reflect the confidence intervals (95%) for the fitted values.