Research Paper Volume 13, Issue 21 pp 23936—23952

Impaired glucose metabolism reduces the neuroprotective action of adipocytokines in cognitively normal older adults with insulin resistance


Figure 2. Moderating role of HOMA-IR and glycemia in the association between the Ad/L ratio and cortical thickness. (A) Results of the three-way interaction (Ad/L ratio × HOMA-IR × glycemia) after adjustment for the remaining MtbS components, CRF, BMI, age, sex and years of education. Significant t statistic values were projected into the inflated cortical surfaces (L: left; R: right). (B) Scatterplot to represent the post-hoc of the three-way interaction effect shown in panel (A). It shows the association of the Ad/L ratio with cortical thickness in the rostral anterior cingulate (rACC) of the right hemisphere at 1 SD below and above the mean of HOMA-IR for participants showing normal blood glucose levels (left panel) and hyperglycemia (right panel). The shaded areas reflect the confidence intervals (95%) for the fitted values.