Research Paper Volume 13, Issue 21 pp 24136—24154

Mutations in DNA damage response pathways as a potential biomarker for immune checkpoint blockade efficacy: evidence from a seven-cancer immunotherapy cohort

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Figure 6.

DDR mutations association with factors in the immune microenvironment. (A) Diverse infiltration abundance of 22 immune cells based on DDR mutational status; (B) Distinct expression of 33 immune checkpoints in patients with and without DDR mutations; (C) Distinct enrichment of 15 immune signatures in patients with and without DDR mutations. *P < 0.05; **P < 0.01; ***P < 0.001.