Research Paper Volume 13, Issue 21 pp 24155—24170

Development of an immune-related signature for predicting survival outcome and immunotherapy response in osteosarcoma

Development of the immune-related risk signature. (A) Regression coefficient profiles of the prognostic immune genes generated by the LASSO model in the TARGET cohort. (B) Partial likelihood deviance representation of distinct gene combination in LASSO regression. The red dots indicated the partial likelihood of deviance values, the gray lines indicated the standard error (SE), the two vertical lines on the left and right respectively indicated optimal values by minimum criteria and 1-SE criteria. (C) Heatmap of the 21 immune-related genes within the identified immune signature and the risk score curve based on the LASSO coefficients. OS patients were stratified into high-risk and low-risk subgroups with the median risk score.

Figure 1. Development of the immune-related risk signature. (A) Regression coefficient profiles of the prognostic immune genes generated by the LASSO model in the TARGET cohort. (B) Partial likelihood deviance representation of distinct gene combination in LASSO regression. The red dots indicated the partial likelihood of deviance values, the gray lines indicated the standard error (SE), the two vertical lines on the left and right respectively indicated optimal values by minimum criteria and 1-SE criteria. (C) Heatmap of the 21 immune-related genes within the identified immune signature and the risk score curve based on the LASSO coefficients. OS patients were stratified into high-risk and low-risk subgroups with the median risk score.