Research Paper Volume 13, Issue 21 pp 24155—24170

Development of an immune-related signature for predicting survival outcome and immunotherapy response in osteosarcoma

The risk signature predictive of immune infiltration and immunotherapy response indicators. (A) A total of 31 lymphocytes infiltration in low-risk versus high-risk subgroups was evaluated by the Angelova et al. algorithm. Pathways involved in immune response, such as (B) interferon γ response, (C) interferon α response, and (D) inflammatory response were markedly enriched in OS patients with low-risk signature scores. The elevated enrichment of immunotherapy efficacy predictors of (E) T cell-inflamed signature, (F) IFNγ signature, and (G) cytolytic activity signature were also connected with low-risk scores.

Figure 3. The risk signature predictive of immune infiltration and immunotherapy response indicators. (A) A total of 31 lymphocytes infiltration in low-risk versus high-risk subgroups was evaluated by the Angelova et al. algorithm. Pathways involved in immune response, such as (B) interferon γ response, (C) interferon α response, and (D) inflammatory response were markedly enriched in OS patients with low-risk signature scores. The elevated enrichment of immunotherapy efficacy predictors of (E) T cell-inflamed signature, (F) IFNγ signature, and (G) cytolytic activity signature were also connected with low-risk scores.