Research Paper Volume 13, Issue 21 pp 23953—23980

UBB+1 reduces amyloid-β cytotoxicity by activation of autophagy in yeast

The global transcriptional response to constitutively low UBB+1 expression. (A) Principal Component Analysis (PCA) of the normalized microarray data. (B–C) Volcano plot of log2(FC) (Fold change) vs adjusted p value of differentially expressed genes comparing L-UBB+1 strain and control strain during EX (B) and D6 (C). The dashed vertical grey line indicates the threshold of log2(FC) (≤ -1 or ≥ 1), while the horizontal grey line indicates statistical significance threshold of adjusted p value D) The significantly enriched GO terms in L-UBB+1 strain compared to control strain during EX and D6 phases. The red color indicates upregulated processes and blue color indicates downregulated processes. Samples are biological duplicates.

Figure 1. The global transcriptional response to constitutively low UBB+1 expression. (A) Principal Component Analysis (PCA) of the normalized microarray data. (BC) Volcano plot of log2(FC) (Fold change) vs adjusted p value of differentially expressed genes comparing L-UBB+1 strain and control strain during EX (B) and D6 (C). The dashed vertical grey line indicates the threshold of log2(FC) (≤ -1 or ≥ 1), while the horizontal grey line indicates statistical significance threshold of adjusted p value < 0.05. (D) The significantly enriched GO terms in L-UBB+1 strain compared to control strain during EX and D6 phases. The red color indicates upregulated processes and blue color indicates downregulated processes. Samples are biological duplicates.