Research Paper Volume 13, Issue 21 pp 24313—24338

Establishment of a tumor immune microenvironment-based molecular classification system of breast cancer for immunotherapy

Immune-activated and -suppressed status of the tumor niche. (A) Co-staining of CD8 and IFN-γ in immune-activated and -suppressed patients. (B) Co-staining of CD8 and granzyme B in immune-activated and -suppressed patient samples. (C) Co-staining of CD45 and TGF-β1 in immune-activated and -suppressed patient samples. (D) Co-staining of CD8 and PD-1 in immune-activated and -suppressed patient samples. Scale bar, 100 μm. Abbreviations: Immu-act: immune-activated; Immu-sup: immune-suppressed.

Figure 3. Immune-activated and -suppressed status of the tumor niche. (A) Co-staining of CD8 and IFN-γ in immune-activated and -suppressed patients. (B) Co-staining of CD8 and granzyme B in immune-activated and -suppressed patient samples. (C) Co-staining of CD45 and TGF-β1 in immune-activated and -suppressed patient samples. (D) Co-staining of CD8 and PD-1 in immune-activated and -suppressed patient samples. Scale bar, 100 μm. Abbreviations: Immu-act: immune-activated; Immu-sup: immune-suppressed.