Research Paper Volume 13, Issue 21 pp 24313—24338

Establishment of a tumor immune microenvironment-based molecular classification system of breast cancer for immunotherapy

Association between immune-related molecular subclasses and molecular characteristics. (A–F) Copy number deletion at the arm level (A), TMB (B), neoantigens (C), TIL abundance (D), and PD-1/PD-L1 mRNA expression levels (E, F) were compared between patients in the immune and non-immune subclasses. (G) Oncoprint of differentially mutated tumor-related genes among the three immunophenotypes. Abbreviations: TIL: tumor-infiltrating lymphocytes; TMB: tumor mutant burden; NeoAg: neoantigen. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, or ****P ≤ 0.0001.

Figure 5. Association between immune-related molecular subclasses and molecular characteristics. (AF) Copy number deletion at the arm level (A), TMB (B), neoantigens (C), TIL abundance (D), and PD-1/PD-L1 mRNA expression levels (E, F) were compared between patients in the immune and non-immune subclasses. (G) Oncoprint of differentially mutated tumor-related genes among the three immunophenotypes. Abbreviations: TIL: tumor-infiltrating lymphocytes; TMB: tumor mutant burden; NeoAg: neoantigen. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, or ****P ≤ 0.0001.